Martin Scorsese has regrets over iconic film he made with Leonardo DiCaprio

Director Martin Scorsese once hinted he had second thoughts about one of his most popular films.

Considered by many as one of the greatest directors of all time, Scorsese, 81, is the face behind some of the most iconic movies ever made.

From the Palme d’Or-winning Taxi Driver to 1980’s Raging Bull starring Robert De Niro, the creative is often applauded for his violent depiction of American culture and his frequent collaborations with various famous faces.

One of these is DiCaprio, 49, who appeared in his first Scorsese film in 2002, the epic historical drama, Gangs of New York.

Two years later, the pair collaborated again on The Aviator before the Titanic favorite appeared as Trooper William ‘Billy Costigan Jr. in 2006’s The Departed.

2010 saw Scorsese and DiCaprio team up for a fourth time in Shutter Island, and later again in The Wolf of Wall Street (2013) and 2015’s The Audition.

Leonardo DiCaprio has starred in six of Martin Scorsese's films (Paramount Pictures)

Their latest project, Killers of the Flower Moon, was released last October but was snubbed at the 96th Academy Awards despite being nominated in ten categories, including Best Director and Best Picture.

Interestingly, Scorsese seemingly isn’t impressed by everything that he and DiCaprio have done together.

The director has previously admitted he wasn’t too fond of Shutter Island - a psychological flick based on the novel of the same name by Dennis Lehane.

The movie saw DiCaprio portraying a US Marshal sent to a remote island to investigate a missing patient - or so we are led to believe.

And while the film is well-liked enough by fans, earning an audience score of 77 percent on Rotten Tomatoes as well as 8.2/10 on IMDb, Scorsese doesn't appear to be that big of a fan.

In an interview with GQ, the Hollywood hero explained that Shutter Island came about after The Departed won him his Best Director Oscar.

The victory 'encouraged [Scorsese] to make another picture’, with the result being Shutter Island.

Looking back, however, Scorsese indicated that wasn't the best move.

"It turned out I should have gone on probably to do Silence," he said.

Silence was released in 2016, and starred Liam Neeson and Andrew Garfield in an epic historical drama.

The filmmaker didn't elaborate further on why he 'probably' should have skipped over Shutter Island, but he went on to acknowledge that the project was 'the last studio film' he made.

Since then, the director has sought to rely on independent studios to fund his films, though they're mostly still distributed theatrically by Paramount.

Scorsese described having previously accepted that he wouldn't be a director who won a lot of awards, adding: "Sure, I would’ve liked it, but like, so what? I mean, I had to go on and make pictures.

The director expressed his feelings on Shutter Island in an interview (Paramount Pictures)

"I don’t know if I think like them," he continued, referring to bigger studios. "I just mind my own business here.”

Scorsese added: "Well, the industry is over. In other words, the industry that I was part of, we’re talking almost, what, 50 years ago? It’s like saying to somebody in 1970 who made silent films, what do you think’s happened?

“[Studios are not] interested any longer in supporting individual voices that express their personal feelings or their personal thoughts and personal ideas and feelings on a big budget. And what’s happened now is that they’ve pigeonholed it to what they call indies.”